Fat-Sensing Hormones Might Fight Obesity
Los Angeles – There is a tiny molecule that exists in the small intestine that sends a signal to the brain that registers the impact of the amount of fat consumed. With the plethora of family and work related holiday parties during this time of year, this little hormone is bound to be working overtime.
Presently, the signal sent from this little hormone does us little more good than keeping us from tripping over our feet to return to the buffet for thirds. However, scientists are attempting to manufacture variations on this family of human hormones (scientific name N-acylphosphatidylethanolamines, or NAPEs) in order to be used as a consistent appetite suppressant in the treament of obesity.
Researchers say that while they are excited about the possibilities of the NAPEs, they are still acting on the side of caution. They are not going to take it to the public until their work on the creation of a viable product is complete. While there is a desparate need for an effective treatment of obesity in today’s population, releasing a drug before it was proven safe and effective would cause more harm than good.
If there were an administerable form of this hormone released to the public before its time that did not work properly, people would only be further discouraged to fight obesity, which would be a detriment rather than a help to the problem. If it were released and had side effects that were not discovered through thorough testing then people could suffer for its use.
Currently tests are being conducted on rats and mice in laboratory settings that are aimed at the discovery of a fat derived signal that could be harnassed to regulate food consumption. One of the sensitive tests used by researchers, the LC tandem mass spectrometry, was responsible for identifying the NAPE group of fat sensing molecules.
When rats and mice were routinely administered NAPEs through a catheter in the jugular, they consumed less, and lost weight. Therefore, it is evident that this small intestine-derived hormone does work in the inhibition of food intake. While the NAPEs do work in the suppression of appetite (therefore decreasing food intake) the drive to feed is a deep and complex human instinct. There are many various factors that contribute to eating disorders. Nonetheless, these research findings on the appetite suppressing hormones of the NAPE are interesting and invigorating. Hopefully medical science will be able to sythesize these molecules released naturally by the gut in order to administer to humans in a supplement form.
Scientists plan to move up the species ladder to see if the NAPEs have the same effects on animals more closely related to humans. If the results are positive, and the NAPEs seem to be safe, human trials could begin shortly after.
I lost a lot of weight using this product, ” There was a three hundred pound that lost weight on this product as well.”
Yvonne, how could you have lost weight on this medication if it has only been tested on laboratory rats!! Are you a rat or just stupid? There are no miracle cures, no magic pills and most products that claim weight loss are nothing more than a scam, frauds, and schemes to get your money for nothing. Diet and exercise are the only ways to lose weight. Americans are fat and lazy. They are slothful and run for the easy fix on life. Easy salvation, easy weight lost, easy relationships. It’s the mantra for the sick, perverted way of life we have expected and demanded.
You want to lose weight? Get off your lazy fat ass and exercise and stop cramming your pie hole with food!
How about using a treadmill desk? These work and don’t require pills. You can find a few models searching on the internet. Walk and work and regain your health. Waiting on pills seems like such a waste .
While it is indeed true that many of us are overweight because we overeat and don’t get enough exercise, I think Ashay is being a little harsh. A major problem with losing weight is that as you restrict calories the body does what evolution has programmed it to do and metabolism rate drops. Exercise can and dose help, but once the weight is off, unless you have built up a large muscle mass, you must exercise more at 150lbs to keep the weight off or continue to lose, than you would if you weighed 400lbs. Our bodies are almost programmed to fail at weight loss. Am I saying you shouldn’t try? No, but I am saying that everyone should show a bit more compassion and understanding about obesity and weight loss. If you have never tried to loose weight and keep it off, you have no idea how hard it is.
I am not lazy and until an accident that broke both my legs and right hip, was very athletic. I was in cast for 12 months, 2 surgeries, and gained 150 pounds. It hurts to walk, much less treadmill, go to park, exercise. What am I to do Ahsay?
You must not be from these parts, and with your attitude, no wonder Americans hate you.
you dont have to be a hater to think that the american way of life is far to convenience based… yes we need more excercise, better diets etc… but you dont have to act like a total jerk to other people. Some peole really just have a plethera of factors working against them-depression, bad genes and so on. Then add the society that we are raised in. Have you never visited Mc donald’s Ahsay? And if you haven’t I would say it is because you have more money than a lot of other people…. Other than that, I pretty much agree agree: botox and diet pills and fast food are ridiculous and uneccesary commodoties of the American life.
I too have used this drug with great success. I lost over 420 pounds!
The best way to lose weight is to cook your own food. This means making all three meals at home. Taking time to know what you are putting in your body. Eat lots of fiber and take your dog for a walk at least twice a day.
You are what you eat.
Start by loving yourself. Make your meals at home. Stop counting calories and learn to enjoy your food.
what can i do? I want to lose weight 5 kg. Now, i’m 61kg and 1.68 metre.
Another way to keep people eating, meaning consuming until they die! There is a simple way: Eat real food! Michael Pollan lays it out nicely in his book “In Defense Of Food”. Drugs are great! No need to change anything about the way we live, just pop a pill and all is good. Look behind the curtain and you’ll see that we are all just puppets on a string, controlled by the corporations and their marketing campaigns. Wake up!!
Sonia colocho is right eat only what you cook at home and if you ain’t got a dog, go out and pull the weeds in your yard. Lose weight and have the best looking lawn in the neighborhood.
What is that? Is that One Ball?
Ok, first of all, to ‘Beamd’….are you for real? Did you read what the purpose of the drug was or did you just not know how to google the phrase ‘appetite suppressant’? Oy vey man. Like fat people don’t already have enough problems.
Comprehension is critical, my friend.
Empathy and compassion are great, too. Also, a general working knowledge of science/biology would help a lot. I say this because to break your chains of ignorance, you first need to know what the hell you’re talking about. Since you imply you believe fat people ate their way to the plus size department, you clearly demonstrate you lack all of the aforemention traits.
Take it from me: you sound like an ignorant shmuck. You should really look into stopping that.
MM
Most of the comments here are useless and would better serve if left unsaid. Now for some suggestions that might be helpful if used reliegiously. There are three sets of musceles if exercised at each meal will help. This is only the start. These musceles are the neck and arm and leg. When you have eaten enough shake your head back and forth to say no to any more, then use your arms to push yourself from the table and the legs walk away.
Most excess fat is caused by people eating to much. The cause of overeating is many and varied. One cause could be all of the food you encounter each and every day augmented by the lack of will power to turn down food that you don’t need. Depression can also cause a person to overeat. Other medical problems are a much lesser cause.
Ahsay, you are a sad example of a human being. Yvonne, don’t pay any attention to the comment by Ahsay. This ignorant person needs to experience some “real” pain and hardship to understand what some others go through. Ahsay is the lazy, stupid and disgusting one…not you! Life is NOT ALWAYS about the choices we make! Sometimes there is no choice! Ahsay….have some compassion….you idiot! Go do some reading and learn about these situations that you obviously know nothing about. And by the way, there are overweight people everywhere….Not just in America!
The people who say they already took this experimental drug actually used a natural product named PEA (phosphatidyl ethanolaminde), available in good health food stores.
In America, hypothyroidism (an underactive thyroid) is an unrecognized epidemic that is associated closely with obesity. The correct blood test is a TSH and Free T3. TSH alone is not the right test. Go to the Broda Barnes Foundation website, and also to Stopthethyroidmadness.com for excellent, eye-opening discussions of this widespread problem. It is VERY difficult for someone who is hypothyroid to lose weight, even with severe dieting and exercise.
Lastly, there are a number of effective natural substances that help boost metabolism. I have used Forskolin, Hydroxy citrate and especially Bitter orange with good success on patients.
Ahsay,
You be quite rude!
First, I’m from Toronto, born and raised! — I’m not American
Second, I took a similar hormone-based product that helped me. Ahsay, there are people like me whose metabolismm does not function properly and suffer
I to have used this drug and lost 3,000 lbs and my mind.